PGT-SR
PGT for chromosomal structural rearrangements (PGT-SR)
Approximately 1 in 3 couples who experience two or more miscarriages will have one or both of the couple with a balanced chromosomal translocation. People with balanced chromosomal translocation usually appear healthy and are unaware they carry a translocation. A balanced chromosomal translocation occurs when either a. 2 segments of different chromosomes break off and swap places (Reciprocal Translocations), b. two chromosomes join (Robertsonian Translocations), or c. when a segment of a chromosome is flipped upside down (Inversions).
Who should use PGT-SR?
![PGT-SR](https://thaisuperiorart.com/wp-content/uploads/2020/09/pgt-a-icon-2.png)
Couples with a chromosomal translocation
![PGT-SR](https://thaisuperiorart.com/wp-content/uploads/2020/09/pgt-ma-icon-03.png)
Couples who have a child affected with a chromosomal disorder
![PGT-SR](https://thaisuperiorart.com/wp-content/uploads/2020/09/pgt-a-icon-4.png)
Couples with a history of two or more miscarriages due to chromosomal disorders or unknown causes
PGT-SR can be tested using either one of the following methods.
![PGT-SR](https://www.thaisuperiorart.com/wp-content/uploads/2020/09/pgt-sr-graphic-methods.png)
![PGT-SR](https://thaisuperiorart.com/wp-content/uploads/2020/09/pgt-sr-icon-04.png)
NGS-SR :
NGS is performed to analyze for a balanced set of all 23 pairs of chromosomes. Then a balanced embryo can be transferred.
![PGT-SR](https://thaisuperiorart.com/wp-content/uploads/2020/09/pgt-sr-icon-05.png)
Karyomapping :
This latest technology is used where couples want to check balanced embryos for carrier or non-carrier of the translocation, and only transfer non-carriers if available.